Antiemetic Drugs Compatibility Evaluation with Paediatric Parenteral Nutrition Admixtures

Chemotherapy-induced nausea and vomiting are defined as the most common of side effects treatment and, at same time, very difficult to accept for patients’, frequently causing changes in therapy regimen, significantly reducing its effectiveness. Thus, an antiemetic prophylactic is essential provision such a patient. Pharmacotherapy often includes various drugs, including antiemetics, with administration drugs by injection through two separate catheters being preferred method. However, co-administration parenteral nutrition admixtures (PNAs) requires consideration compatibility, stability potential negative interactions. To meet purposes clinical pharmacy, compatibility test ondansetron, dexamethasone hydrocortisone paediatric PNAs was conducted. differ composition amino acid source (Primene® or Aminoplasmal Paed® 10%) type injectable lipid emulsion (Lipidem® 200 mg/mL, Clinoleic® 20%, SMOFlipid® Intralipid® 20%). An vitro evaluation performed static way simulated Y-site. The drug PNA ratios were determined based on extreme infusion rates contained characteristics medicinal products. All calculations hypothetical patient aged 7 years weighing 24 kg. As result this study, it can be concluded that all tested showed required range parameters pH, osmolality, turbidity, zeta potential, MDD homogeneity. does not adversely affect stability. This combination consistently compatible during period.